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Here's what the data shows

However, as mentioned previously for vagal afferent regulation of food intake, recent work has failed to demonstrate an effect of food intake via direct gut peptide signaling on VAN-localized receptors

Mantovani, G., Maccio, A., Madeddu, C., Serpe, R., Massa, E., Dessi, M., Panzone, F., and Contu, P

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